For some applications where the target device is connected to the main earth (ground), the non isolation of the power profiler may be a problem. It could pick-up noise and can cause small offsets in measurement. In order to solve this ground loop, we recommend to use a high speed USB isolator which runs at 480Mbps.
We have tested a product named Hifime High-Speed USB Isolator and found to be working fine with the IOT Power Profiler. It provides isolated USB port which can be used with grounded loads with greater accuracy.
Note that any USB isolator would not work. It has to work at 480Mbps and should be able to provide at least 200mA to the power profiler. Most USB isolators out in the market work only at 12Mbps and not at the high speed.